Method for preparation of fluoro alkylated compounds by homogeneous Ni catalysis

ABSTRACT

The invention discloses a method for the preparation of fluoro alkylated compounds by homogeneous Ni catalyzed fluoro alkylation with fluoro alkyl halides in the presence of a base.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is the U.S. National Stage entry of International Application Number PCT/EP2020/054542 filed under the Patent Cooperation Treaty having a filing date of Feb. 20, 2020, which claims priority to U.S. Provisional Patent Application No. 62/807,899 having a filing date of Feb. 20, 2019, and European Patent Application No. 19158332.7 having a filing date of Feb. 20, 2019, which are incorporated herein by reference.

TECHNICAL FIELD

The invention discloses a method for the preparation of fluoro alkylated compounds by homogeneous Ni catalyzed fluoro alkylation with fluoro alkyl halides in the presence of a base.

BACKGROUND OF THE INVENTION

Organofluorine chemistry plays an important role in medicinal, agricultural, and material sciences and fields. Fluoroalkyl groups have strong effects such as high stability and lipophilicity, in addition, longer fluoroalkyl groups have high water and oil resistance and low friction.

-   Loy, R. N., et al., Organic Letters 2011, 13, 2548-2551, discloses     Pd-catalyzed coupling of CF₃—I with benzene in 26% GC yield.

According to Table 1 entry 10 the coupling of C₆F₁₃I provided 81% yield.

But a repetition of this experiment with the bromide instead of the iodide provided less than 1% yield, see Comparative Example herein.

There was a need fora homogenous catalyzed method for the preparation of fluoro alkylated compounds by direct C—H fluoro methylation, which provides high yields but does not need the assistance of a directing group or of electron rich aromatic compounds. The method should be applicable to a wide variety of substrates and should be compatible with a wide variety of functional groups. Furthermore the method should not be restricted to iodides as alkylating agents only, but should also work with bromides.

Unexpectedly a reaction with homogenous Ni catalysis was found that meets these requirements. No dialkylated products are observed. Only small exchange of the halide against H in the fluoro alkylated halide is observed.

ABBREVIATIONS

In this text, the following meanings are used, if not otherwise stated:

-   alkyl linear or branched alkyl, preferably linear; -   DME 1,2-dimethoxyethane -   dppb 1,4-Bis(diphenylphosphino)butane, compound 0 formula (dppb)

-   dppf 1,1′-Bis(diphenylphosphino)ferrocen, compound of formula (4)

-   eq, equiv equivalent -   halogen F, Cl, Br or I; preferably F, Cl or Br; more preferably F or     Cl -   “linear” and “n-” are used synonymously with respect to the     respective isomers of alkanes -   MTBE methyl tert-butyl ether -   Ni-cat2 (dppf)Ni(o-tol)Cl -   PfP-H 1,1,1,2,3,3,3-heptafluoropropane -   PhB-acid Phenylboronic acid, compound of formula (5)

-   PhbP triphenylphosphine -   PMHS polymethylhydrosiloxane -   RT room temperature, it is used synonymously with the expression     ambient temperature -   “wt %”, “% by weight” and “weight-%” are used synonymously and mean     percent by weight

SUMMARY OF THE INVENTION

Subject of the invention is a method for the preparation of a fluoro alkylated compound FACOMPSUBST by a reaction of a compound COMPSUBST with a fluoro alkyl halide FAHALIDE by homogeneous catalysis using a Ni catalyst NICAT in the presence of a base BAS;

-   wherein -   NICAT is Ni-cat1 or Ni-cat2;     -   Ni-cat1 is a combination of a nickel salt NISALT with a ligand         LIG         -   NISALT is NiCl₂ or Ni(NO₃)₂;         -   LIG is selected from the group consisting of compound of             formula (DPEPhos), compound of formula (dppb) and Ph₃P;

-   -   Ni-cat2 is compound of formula (Ni-cat2);

-   BAS is selected from the group consisting of Cs₂CO₃, CsHCO₃, K₃PO₄,     NaH and NaOtBu; -   FAHALIDE is a compound of formula (FAHALIDE);     X2-R3-X1  (FAHALIDE)     -   R3 is C₁₋₂₀ alkylen, wherein in the alkylen chain at least one         of the hydrogens is substituted by F;     -   X1 is Br or I;     -   X2 is Br or H; -   COMPSUBST is selected from the group consisting of a compound     COMPSUBST-I, ethene, cyclohexene, ethine, and polystyrene; -   the ethene and the cyclohexene being unsubstituted or substituted by     1, 2 or 3 substitutents selected from the group consisting of C₁₋₁₀     alkyl, C₃₋₈ cycloalkyl, C₁₋₄ alkoxy, N(R10)R11, CN, NO, NO₂, F, Cl,     Br, I, CF₃, (CH₂)_(m)—C(O)Y1, S(O)₂R50, CH═C(H)R28, C     C—R24, benzyl, phenyl, naphthyl and morpholine; -   the ethine being unsubstituted or substituted by 1 substitutent     selected from the group consisting of C₁₋₁₀ alkyl, C₃₋₈ cycloalkyl,     C₁₋₄ alkoxy, N(R10)R11, CN, NO, NO₂, F, Cl, Br, I, CF₃,     (CH₂)_(m)—C(O)Y1, S(O)₂R50, CH═C(H)R28, C     C—R24, benzyl, phenyl and naphthyl; -   COMPSUBST-I is a compound of formula (COMPSUBST-I)     RINGA  (COMPSUBST-I) -   RINGA is an aromatic 5 or 6 membered carbocyclic or heterocyclic     ring,     -   when RINGA is a heterocyclic ring, then RINGA has 1, 2 or 3         identical or different endocyclic heteroatoms independently from         each other selected from the group consisting of N, O and S,     -   when RINGA is a 5 membered ring, then RINGA is unsubstituted or         substituted by 1, 2, 3 or 4 identical or different         substitutents,     -   when RINGA is a 6 membered ring then RINGA is unsubstituted or         substituted by 1, 2, 3, 4 or 5 identical or different         substitutents,     -   any of said substitutents of RINGA is independently from any         other of said substitutents of RINGA selected from the group         consisting of C₁₋₁₀ alkyl, C₃-8 cycloalkyl, C₁₋₄ alkoxy, OH,         N(R10)R11, CN, NH—OH, NO, NO₂, F, Cl, Br, I, CF₃,         (CH₂)_(m)—C(O)Y1, S(O)₂R50, CH═C(H)R28, C         C—R24, benzyl, phenyl and naphthyl; -   RINGA can be condensed with a ring RINGB, RINGB is a 5 or 6 membered     carbocyclic or heterocyclic ring, -   when RINGB is a heterocyclic ring, is contains 1, 2 or 3 identical     or different endocyclic heteroatoms independently from each other     selected from the group consisting of N, O and S; -   when RINGB is a 5 membered ring, then RINGB is unsubstituted or     substituted by 1, 2 or 3 identical or different substitutents, -   when RINGB is a 6 membered ring then RINGB is unsubstituted or     substituted by 1, 2, 3 or 4 identical or different substitutents, -   any of said substitutents of RINGB is independently from any other     of said substitutents of RINGB selected from the group consisting of     C₁₋₁₀ alkyl, C₃₋₈ cycloalkyl, C₁₋₄ alkoxy, OH, N(R17)R18, CN, NH—OH,     NO, NO₂, F, Cl, Br, I, CF₃, (CH₂)_(n)—C(O)Y2, S(O)₂R51, CH═C(H)R38,     C     C—R34, benzyl, phenyl and naphthyl; -   any of said C₁₋₁₀ alkyl substitutent of RINGA or RINGB is     unsubstituted or substituted with 1, 2, 3, 4 or 5 identical or     different substituents selected from the group consisting of     halogen, OH, O—C(O)—C₁₋₅ alkyl, O—C₁₋₁₀ alkyl, S—C₁₋₁₀ alkyl,     S(O)—C₁₋₁₀ alkyl, S(O₂)—C₁₋₁₀ alkyl, O—C₁₋₆ alkylen-O—C₁₋₆ alkyl,     C₃₋₈ cycloalkyl and 1,2,4-triazolyl; -   any of said benzyl, phenyl and naphthyl substitutent of RINGA or     RINGB is independently from each other unsubstituted or substituted     with 1, 2, 3, 4 or 5 identical or different substituents selected     from the group consisting of halogen, C₁₋₄ alkoxy, NO₂ and CN; -   m and n are identical or different and independently from each other     0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; -   Y1 and Y2 are identical or different and independently from each     other selected from the group consisting of H, OH, C(R14)(R15)R16,     C₁₋₆ alkyl, O—C₁₋₆ alkyl, phenyl, benzyl, O-phenyl, O—C₁₋₆     alkylen-O—C₁₋₆ alkyl and N(R19)R20;     -   R14, R15 and R16 are identical or different and independently         from each other selected from the group consisting of H, F, Cl         and Br; -   R10, R11, R17, R18, R19 and R20 are identical or different and are     independently from each other H or C₁₋₆ alkyl, or R10 and R11, R17     and R18 or R19 and R20 represent together a tetramethylene or a     pentamethylene chain; -   R50 and R51 are identical or different and independently from each     other selected from the group consisting of OH, C₁₋₆ alkyl and C₁₋₆     alkoxy; -   R24, R34, R28 and R38 are identical or different and independently     from each other selected from the group consisting of H, C₁₋₁₀     alkyl, C(R25)(R26)-O—R27;     -   R25, R26 and R27 are identical or different and independently         from each other selected from the group consisting of H and         C₁₋₁₀ alkyl.

DETAILED DESCRIPTION OF THE INVENTION

Preferably, when LIG is Ph₃P then NISALT is Ni(NO₃)₂.

Preferably, when LIG is compound of formula (dppb) then NISALT is NiCl₂.

Preferably, LIG is compound of formula (DPEPhos) or Ph₃P.

Preferably, Ni(NO₃)₂ is used in form of its hydrate Ni(NO₃)₂ 6H₂O.

-   NiCl₂ can be used as such or as NiCl₂(DME); NiCl₂(DME) is a mixture     of NiCl₂ and 1,2-dimethoxyethane in the molar ratio of 1:1; -   preferably NiCl₂ is used as NiCl₂(DME).

Preferably, BAS is selected from the group consisting of Cs₂CO₃, K₃PO₄, NaH and NaOtBu; more preferably,

-   -   BAS is Cs₂CO₃ or K₃PO₄, when COMPSUBST is COMPSUBST-I or         polystyrene;     -   BAS is NaH or NaOtBu, when COMPSUBST is the ethene, the         cyclohexene or the ethine.

Preferably, m and n are identical or different and independently from each other 0, 1, 2, 3 or 4; more preferably, m and n are identical or different and independently from each other 0 or 4.

-   Preferably, Y1 and Y2 are identical or different and independently     from each other selected from the group consisting of H, OH, C₁₋₂     alkyl, and O—C₁₋₂ alkyl.

Preferably, COMPSUBST is selected from the group consisting of compound COMPSUBST-I, ethene, cyclohexene, ethine, and polystyrene;

-   the ethene and the cyclohexene being unsubstituted or substituted by     1 or 2 substitutents selected from the group consisting of C₁₋₁₀     alkyl, C₃₋₆ cycloalkyl, C₁₋₄ alkoxy, N(R10)R11, CN, F, Cl, Br, I,     CF₃, (CH₂)_(m)—C(O)Y1, S(O)₂R50, benzyl, phenyl, naphthyl and     morpholine; -   the ethine being unsubstituted or substituted by 1 substitutent     selected from the group consisting of C₁₋₁₀ alkyl, C₃₋₆ cycloalkyl,     C₁₋₄ alkoxy, N(R10)R11, CN, F, Cl, Br, I, CF₃, (CH₂)_(m)—C(O)Y1,     S(O)₂R50, benzyl, phenyl and naphthyl; -   with COMPSUBST-I being selected from the group consisting of

-   with COMPSUBST-I being unsubstituted or substituted     -   by 1, 2, 3 or 4 in case of COMPSUBST-I being a monocyclic         compound with 5 endocyclic atoms,     -   by 1, 2, 3, 4 or 5 in case of COMPSUBST-I being a monocyclic         compound with 6 endocyclic atoms,     -   by 1, 2, 3, 4, 5 or 6 in case of COMPSUBST-I being a bicyclic         compound wherein a 5-membered and a 6-membered ring are         ortho-fused,     -   by 1, 2, 3, 4, 5, 6 or 7 in case of COMPSUBST-I being a bicyclic         compound wherein two 6-membered rings are ortho-fused, -   identical or different substituents independently from each other     selected from the group consisting of C₁₋₁₀ alkyl, C₃₋₈ cycloalkyl,     C₁₋₄ alkoxy, OH, C(H)═O, N(R10)R11, CN, NH—OH, NO, NO₂, F, Cl, Br,     I, CF₃, (CH₂)_(m)—C(O)Y1, S(O)₂R50, CH═C(H)R28, C     C—R24, benzyl, phenyl and naphthyl; -   said C₁₋₁₀ alkyl substitutent of COMPSUBST-I is unsubstituted or     substituted with 1, 2, 3, 4 or 5 identical or different substituents     selected from the group consisting of halogen, OH, O—C(O)—C₁₋₅     alkyl, O—C₁₋₁₀ alkyl, S—C₁₋₁₀ alkyl, S(O)—C₁₋₁₀ alkyl, S(O₂)—C₁₋₁₀     alkyl, O—C₁₋₆ alkylen-O—C₁₋₆ alkyl, C₃₋₈ cycloalkyl and     1,2,4-triazolyl; -   said benzyl, phenyl and naphthyl substitutents of COMPSUBST-I are     independently from each other unsubstituted or substituted with 1,     2, 3, 4 or 5 identical or different substituents selected from the     group consisting of halogen, C₁₋₄ alkoxy, NO₂ and CN; -   with R10, R11, m, Y1, R28, R50, R24 and halogen as defined herein,     also with all their embodiments.

More preferably, COMPSUBST-I is unsubstituted or substituted

-   -   by 1, 2 or 3 in case of COMPSUBST-I being a monocyclic compound         with 5 endocyclic atoms,     -   by 1, 2, 3, 4 or 5 in case of COMPSUBST-I being a monocyclic         compound with 6 endocyclic atoms,     -   by 1, 2, 3 or 4 in case of COMPSUBST-I being a bicyclic compound         wherein a 5-membered and a 6-membered ring are ortho-fused,     -   by 1, 2, 3, 4 or 5 in case of COMPSUBST-I being a bicyclic         compound wherein two 6-membered rings are ortho-fused,

-   identical or different substituents independently from each other     selected from the group consisting of C₁₋₄ alkyl, C₁₋₄ alkoxy, OH,     C(H)═O, N(R10)R11, CN, F, Cl, Br, CF₃, (CH₂)_(m)—C(O)Y1, and     S(O)₂R50;

-   said C₁₋₄ alkyl substitutent of COMPSUBST-I is unsubstituted or     substituted with 1, 2 or 3 identical or different substituents     selected from the group consisting of halogen;

-   with R10, R11, m, Y1, R50 and halogen as defined herein, also with     all their embodiments.

Especially, COMPSUBST is selected from the group consisting of

ethene, cyclohexene, ethine, and polystyrene;

-   Y is C₁₋₆ alkyl; -   the ethene and the cyclohexene being unsubstituted or substituted by     1 or 2 substitutents selected from the group consisting of C₁₋₁₀     alkyl, C₁₋₄ alkoxy, N(R10)R11, CN, F, Cl, Br, I, CF₃,     (CH₂)_(m)—C(O)Y1, benzyl, phenyl and morpholine; -   the ethine being unsubstituted or substituted by 1 substitutent     selected from the group consisting of C₁₋₁₀ alkyl, C₁₋₄ alkoxy,     N(R10)R11, CN, F, Cl, Br, I, CF₃, (CH₂)_(m)—C(O)Y1, benzyl and     phenyl; -   with R10, R11, m and Y1 as defined herein, also with all their     embodiments.

Preferably, Y is methyl or ethyl;

-   more preferably Y is ethyl.

Embodiments of the substituted ethene are propene, ethene-1,1-diyldibenzene and 3,3-dimethylbut-1-ene:

-   preferably 3,3 dimethylbut 1 ene.

An embodiment of substituted cyclohexene is 4-(cyclohex-1-en-1-yl)morpholine.

An embodiment of the substituted ethine is 1-octyne.

An embodiment of COMPSUBST is compound of formula (PYRAZ)

-   wherein -   Y is methyl or ethyl; -   preferably Y is ethyl.

Preferably, R3 is CMS alkylen, wherein in the alkylen chain at least one of the hydrogens is substituted by F;

-   more preferably, R3 is C₁₋₁₀ alkylen, wherein in the alkylen chain     at least one of the hydrogens is substituted by F.

Especially, FAHALIDE is selected from the group consisting of perfluoro C₁₋₂₀ alkyl-X1, Br—(CF₂)_(n3)—Br, and F₂HC—X1;

-   more especially, FAHALIDE is selected from the group consisting of     perfluoro CMS alkyl-X1, Br—(CF₂)_(n3)—Br or F₂HC—X1; -   even more especially, FAHALIDE is selected from the group consisting     of perfluoro C₁₋₁₀ alkyl-X1, Br—(CF₂)_(n3)—Br or F₂HC—X1; -   with n3 being an integer of 2 to 10; -   preferably, n3 is 2, 3, 4, 5, 6; -   more preferably, n3 is 2, 4 or 6; -   even more preferably, n3 is 4.

In particular, FAHALIDE is selected from the group consisting of F₂₁C₁₀—I, F₂₁C₁₀—Br, F₁₇C₈—I, F₁₇C₈—Br, F₁₃C₆—I, F₁₃C₆—Br, F₉C₄—I, F₉C₄—Br, F₇C₃—I, F₇C₃—Br, F₃C—I, F₃C—Br, Br—(CF₂)₄—Br, F₂HC—I, and F₂HC—Br;

-   more in particular, FAHALIDE is selected from the group consisting     of F₂₁C₁₀—I, F₁₇C₈—I, F₉C₄—I, F₇C₃—I, F₃C—Br, and Br—(CF₂)₄—Br.

In one embodiment,

-   -   X1 is I;     -   X2 is H.

In one embodiment,

-   R3 is perfluoroalkylen.

Preferably, from 0.1 to 20 mol %, more preferably from 0.5 to 15 mol %, even more preferably from 0.5 to 10 mol %, especially from 0.5 to 7.5 mol %, more especially from 0.5 to 6 mol %, even more especially from 0.75 to 5.5 mol %, of NICAT are used in the reaction, the mol % are based on the molar amount of FAHALIDE.

Preferably, from 0.1 to 20 mol %, more preferably from 0.5 to 15 mol %, even more preferably from 1 to 12.5 mol %, especially from 2 to 12.5 mol %, of LIG are used in the reaction, the mol % are based on the molar amount of FAHALIDE.

In case of FAHALIDE being in gaseous form at ambient temperature, then preferably FAHALIDE is used in the reaction in an amount which corresponds to a pressure of from 1 to 20 bar, more preferably from 1 to 15 bar, even more preferably from 1 to 10 bar, especially from 2 to 10 bar, more especially from 3 to 8 bar, even more especially from 4 to 8 bar, at ambient temperature.

Preferably, from 1 to 20 mol equivalents, more preferably 1 to 15 mol equivalents, even more preferably from 2 to 15 mol equivalents, especially from 2 to 12.5 mol equivalents, more especially from 2 to 11 mol equivalents, even more especially from 2.5 to 11 mol equivalents, of COMPSUBST are used in the reaction, the mol equivalents are based on the molar amount of FAHALIDE.

Preferably, from 0.1 to 10 mol equivalents, more preferably from 0.5 to 5 mol equivalents, even more preferably from 0.75 to 5 mol equivalents, especially from 0.85 to 5 mol equivalents, more especially from 0.95 to 5 mol equivalents, even more especially from 0.95 to 4 mol equivalents, in particular from 0.95 to 3 mol equivalents, of BAS are used in the reaction, the mol equivalents are based on the molar amount of FAHALIDE.

The reaction temperature of the reaction is preferably from 20 to 200° C., more preferably from 30 to 175° C., even more preferably from 40 to 175° C., especially from 40 to 150° C.

The reaction time of the reaction is preferably from 1 to 96 h, more preferably from 2 to 84 h, even more preferably from 3 to 80 h, especially from 4 to 76 h.

Preferably, the reaction is done under inert atmosphere. Preferably, the inert atmosphere is achieved by the use if an inert gas preferably selected from the group consisting of argon, another noble gas, lower boiling alkane, nitrogen, more preferably nitrogen.

The lower boiling alkane is preferably a C₁₋₃ alkane, i.e. methane, ethane or propane.

The reaction can be done in a closed system, it can be done at a pressure caused by the reaction mixture at the chosen temperature in a closed system, and/or caused by the pressure applied by COMPSUBST, in case that COMPSUBST is in gaseous form. It is also possible to apply pressure with said inert gas. It is also possible to carry out the reaction at ambient pressure.

The reaction can be done in the presence of a an additive ADD;

-   ADD is selected from the group consisting of Zn,     polymethylhydrosiloxane, and phenylboronic acid.

Preferably, from 1 to 40 mol %, more preferably from 1 to 30 mol %, even more preferably from 1.5 to 30 mol %, especially from 1.5 to 25 mol %, more especially from 2 to 25 mol %, of ADD are used in the reaction, the mol % are based on the molar amount of FAHALIDE.

The reaction can be done in the presence of a an drying agent DRYAG;

-   DRYAG is selected from the group consisting of molecular sieve and     Na₂SO₄; -   preferably, the molecular sieve has a pore size of 4 angstrom.

The molecular sieve is preferably a Na₁₂[(AlO₂)₁₂(SiO₂)₁₂]×H₂O.

Preferably, the amount of DRYAG used in the reaction is from 0.1 to 2 fold, more preferably from 0.1 to 1.5 fold, even more preferably from 0.1 to 1 fold, especially from 0.1 to 0.75 fold, more especially from 0.1 to 0.5 fold, based on the weight of FAHALIDE.

Preferably, the reaction can be done in the presence of DRYAG when NICAT is Ni-cat1.

The reaction can be done neat or in a solvent SOL, SOL is preferably selected from the group consisting of alkanes, chlorinated alkanes, ketones, ethers, esters, aliphatic nitrils, aliphatic amides, sulfoxides, C₆F₆, and mixtures thereof;

-   preferably SOL is selected from the group consisting of C₅₋₈ alkane,     chlorinated C₅₋₈ alkane, acetone, methylethylketone, diethylketone,     MTBE, tetrahydrofuran, methyltetrahydrofuran, ethylacetate,     butylacetate, valeronitril, acetonitrile, dimethylformamide,     dimethylacetamide, N-methylpyrrolidone, dimethylsulfoxide, C₆F₆, and     mixtures thereof; -   more preferably SOL is selected from the group consisting of     acetone, methylethylketone, diethylketone, valeronitril,     acetonitrile, dimethylsulfoxide, C₆F₆, and mixtures thereof; -   even more preferably SOL is selected from the group consisting of     acetone, methylethylketone, diethylketone, dimethylsulfoxide, C₆F₆,     and mixtures thereof; -   especially SOL is C₆F₆.

It is also possible to use COMPSUBST and/or FAHALIDE simultaneously as solvent, meaning that the reaction is done neat.

Preferably, the reaction is done neat or in C₆F₆ as SOL.

The amount of SOL is preferably from 0.1 to 100 fold, more preferably from 1 to 50 fold, even more preferably from 1 to 25 fold, especially from 1 to 12.5 fold, more especially from 1 to 10 fold, even more especially from 3 to 10 fold, of the weight of FAHALIDE.

After the reaction, FACOMPSUBST can be isolated by standard methods such as evaporation of volatile components, extraction, washing, drying, concentration, crystallization, chromatography and any combination thereof, which are known per se to the person skilled in the art.

EXAMPLE Abbreviations

-   4A-MS 4 Angström Molecular sieve, 70955-01-0,     Na₁₂[(AlO₂)₁₂(SiO₂)₁₂]×H₂O -   Conv Conversion in mol % with regard to COMPSUBST -   Sel Selectivity in mol % with regard to COMPSUBST -   Ex Example -   Ni(NO₃)₂ was used as Ni(NO₃)₂ 6H₂O -   Proc Procedure -   T reaction temperature -   t reaction time

General Procedure 1: Ni-Salt and Reduction Additives

A mixture of COMPSUBST, FAHALIDE, NICAT, LIG, BAS, ADD, DRYAG, solvent (all equivalents and amounts are specified in the experimental table) were placed in a thick-walled pressure tube (Ace pressure tube, Sigma-Adrich Art. Nr. Z564575). The gas atmosphere in the pressure tube was flushed with nitrogen, the tube was closed with a screw cap and heated (reaction temperature and reaction time are specified in Table 3). The resulting mixture was cooled to room temperature and diluted with dichloromethane (4 ml). The solids were removed by centrifugation (3000 rpm, 15 min). The obtained product solution was analyzed by quantitative GC analysis (internal standard hexadecane), ¹⁹F-NMR analysis using the internal standards 1,2-difluorobenzene or 1,4-difluorobenzene, or GC-MS.

Isolation of the products was conducted by pipette column chromatography using FluoroFlash® reverse phase silica gel (Sigma Aldrich No.: 00866) and a gradient solvent elution (1. MeOH:H₂O (4:1. 10 mL) 2. MeOH (100%, 10 mL) 3. acetone (100%, 10 mL) for long chains perfluoroalkyl chains (alkyl chain containing 10 or more carbon atoms) or by normal phase silical gel chromatography using silicagel (Sigma Aldrich No.: 236802) and a gradient solvent elution (1. Pentane Ether (100%) 2. Pentane:Diethylether (50%:50%, 10 ml) for perfluoroalkyl chains containing less than 10 carbon atoms.

Procedure “Preformation of Ni-Cat2”

Preformation of Ni-cat2 was done according to Standley, E. A. et al., A Broadly Applicable Strategy for Entry into Homogeneous Nickel(0) Catalysts from Air-Stable Nickel(II) Complexes, Organometallics 2014, 33, 2012:

NiCl₂.6H₂O (8.5 mmol, 2.02 g) and EtOH (25 mL) were placed in an argon flushed round bottom flask equipped with a septum and a reflux condenser (Schlenk-flask). Then dppf (8.5 mmol, 4.712 g) was added and the resulting reaction mixture refluxed for 30 min (temperature ca. 80° C.), before cooled to 0° C. for 10 min. The so formed solid was collected by filtration and washed twice with EtOH (2 times with 10 mL) and with diethylether (2 times with 10 mL). After drying of the solid under vacuum (ca. 20 mbar, room temperature) 4.98 g intermediate Ni-int1, (dppf)NiCl₂, corresponding to 85% yield was obtained as a deep green powder.

This Ni-int1 (6.81 mmol, 4.658 g) and 180 mL CH₂Cl₂ were placed in an argon flushed round bottom flask. The resulting solution was cooled to 0° C., then o-tolylmagnesium chloride (6.81 mmol, 0.945 M in THF, 7.21 mL) was added dropwise with vigorous stirring. Near the end of the addition, the color of the solution changed from green to orange. This solution was stirred for an additional 15 min at 0° C. after addition, then the solvent was evaporated under vacuum at room temperature. Then 25 ml MeOH were added and the reaction mixture was stirred for 5 min at room temperature. After cooling this mixture to 0° C., the solid was collected by filtration, the residue was washed with MeOH (2 times with 5 ml) and dried under vacuum (ca. 5 mbar) at room temperature to yield 4.63 g Ni-cat2, (dppf)Ni(o-tol)Cl, corresponding to 92% yield as a fine, bright yellow powder.

¹H NMR (400 MHz, CD2Cl2): delta=8.23-8.12 (m, 4H), 8.02-7.93 (m, 2H), 7.51-7.38 (m, 7H), 7.27 (td, J=8.3, 2.0 Hz, 2H), 7.21-7.15 (m, 1H), 6.99 (t, J=7.4 Hz, 1H), 6.76 (td, J=8.2, 2.6 Hz, 2H), 6.66-6.54 (t, 2H), 6.43 (t, J=7.4 Hz, 1H), 6.30 (t, J=6.8 Hz, 1H), 6.10 (d, J=7.1 Hz, 1H), 5.15 (s, 1H), 4.54 (m, 1H), 4.25 (s, 1H), 4.19 (s, 1H), 4.02 (d, J=10.1 Hz, 2H), 3.52 (m, 1H), 3.33 (m, 1H), 2.44 (s, 3H).

³¹P NMR (162 MHz, CD2Cl₂): delta=29.51 (d, J=25.9 Hz, 1P), 12.12 (d, J=25.9 Hz, 1P).

General Procedure 2: Fluoroalkylation Using Preformed Ni-Cat2

A mixture of FAHALIDE (1 eq, 0.2 mmol), Ni-cat2 (5 mol %, 0.01 mmol, 7.40 mg, prepared according to the procedure “Preformation of Ni-cat2”), COMPSUBST (10 eq, 2 mmol,) and BAS were placed in a thick-walled Ace pressure tube (Sigma-Aldrich Art. Nr. Z564575). The gas atmosphere in the pressure tube was flushed with nitrogen, the tube was closed with a screw cap and heated for the reaction time and at the reaction temperature specified in the tables. The resulting reaction mixture was cooled to room temperature and diluted with dichloromethane (4 ml).

The solids were removed by centrifugation (3000 rpm, 15 min). The obtained product solution was analyzed by quantitative ¹⁹F-NMR analysis using 1,4-difluorobenzene or 1,2-difluorobenzene as internal standard, quantitative GC analysis using hexadecane as internal standard, or GC-MS.

Isolation of the products was conducted by pipette column chromatography using FluoroFlash® reverse phase silica gel (Sigma Aldrich No.: 00866) and a gradient solvent elution (1. MeOH:H₂O (4:1. 10 mL) 2. MeOH (100%, 10 mL) 3. acetone (100%, 10 mL) for long chains perfluoroalkyl chains (alkyl chain containing 10 or more carbon atoms) or by normal phase silical gel chromatography using silicagel (Sigma Aldrich No.: 236802) and a gradient solvent elution (1. Pentane Ether (100%) 2. Pentane:Diethylether (50%:50%, 10 ml) for perfluoroalkyl chains containing less than 10 carbon atoms.

Details of the examples are given in Tables 1, 2 and 3.

TABLE 1 Ex Proc COMPSUBST FAHALIDE Product  1  1

 2  2

 3  1

 4  1

 5  1

 6  1

 7  1

 8  1

 9  1

10  2

C₁₀F₂₁I

11  2

C₁₀F₂₁I

12  2

C₁₀F₂₁I

13  2

C₁₀F₂₁I

14  2

C₁₀F₂₁I

15  2

C₁₀F₂₁I

16  2

C₁₀F₂₁I

17  2

C₁₀F₂₁I

18  2

C₁₀F₂₁I

19  2

C₁₀F₂₁I

20  2

C₁₀F₂₁I

21  2

C₁₀F₂₁I

22  2

C₁₀F₂₁I

23  2

C₁₀F₂₁I

24  2

C₁₀F₂₁I

25  2

C₁₀F₂₁I

26  2

C₁₀F₂₁I

27  2

C₁₀F₂₁I

28  2

C₁₀F₂₁I

29  2

C₁₀F₂₁I

30  2

C₈F₁₇I

31  2

C₄F₉I

32 22

33  2

34  2

35  2

36  2

37  2

38  2

CF₃Br

39  2

C₁₀F₂₁I

40  2

C₄F₉I

41  2

C₈F₁₇I

42  2

43  2

TABLE 2 COMPSUBST FAHALIDE Ex Proc Amount Amount NICAT LIG ADD BAS 1 1 0.5 ml 0.5 mmol NiCl₂(DME) DPEPhos — Cs₂CO₃ 4 mmol 150 mg 5 mol % 10 mol % 1 eq 1 eq 2 2 0.5 ml 0.5 mmol Ni-cat2 — — Cs₂CO₃ 4 mmol 150 mg 5 mol % 1 eq 1 eq 3 1 0.25 ml 0.5 mmol NiCl₂(DME) DPEPhos — Cs₂CO₃ 2 mmol 150 mg 5 mol % 10 mol % 1 eq 1 eq 4 1 0.25 ml 0.5 mmol NiCl₂(DME) DPEPhos — K₃PO₄ 2 mmol 150 mg 5 mol % 10 mol % 1 eq 1 eq 5 1 0.3 ml 0.5 mmol Ni(NO₃)₂ DPEPhos Zn K₃PO₄ 2.4 mmol 150 mg 5 mol % 6 mol % 15 mol % 1 eq 1 eq 6 1 0.6 ml 0.5 mmol Ni(NO₃)₂ DPEPhos Zn K₃PO₄ 4.8 mmol 150 mg 2.5 mol % 3 mol % 2.5 mol % 1 eq 1 eq 7 1 0.3 ml 0.5 mmol Ni(NO₃)₂ DPEPhos Zn K₃PO₄ 2.4 mmol 150 mg 3 mol % 3 mol % 2.5 mol % 1 eq 1 eq 8 1 0.4 ml 1 mmol Ni(NO₃)₂ DPEPhos Zn K₃PO₄ 3 mmol 300 mg 3 mol % 3 mol % 5 mol % 1 eq 1 eq 9 1 0.2 ml 0.5 mmol Ni(NO₃)₂ Ph₃P PHMS K₃PO₄ 1.6 mmol 150 mg 3 mol % 6 mol % 20 mol % 1 eq 1 eq 10 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 11 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 12 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 13 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 14 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 15 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 16 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 17 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 18 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 19 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 20 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 21 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 22 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 23 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 24 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 25 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 26 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 27 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 28 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 29 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 130 mg 5 mol % 1.5 eq 1 eq 30 2 0.5 ml 0.2 mmol Ni-cat2 — — Cs₂CO₃ 110 mg 5 mol % 1.5 eq 1 eq 31 2 0.5 ml 0.5 mmol Ni-cat2 — — Cs₂CO₃ 170 mg 5 mol % 1.5 eq 1 eq 32 22 0.5 ml 0.5 mmol Ni-cat2 — — Cs₂CO₃ 150 mg 5 mol % 1.5 eq 1 eq 33 2 170 mg 0.5 mmol Ni-cat2 — — Cs₂CO₃ 1 mmol 150 mg 5 mol % 1.5 eq 2 eq 1 eq 34 2 0.5 ml 0.5 mmol Ni-cat2 — — Cs₂CO₃ 150 mg 5 mol % 1.5 eq 1 eq 35 2 0.5 ml 0.5 mmol Ni-cat2 — — Cs₂CO₃ 150 mg 5 mol % 1.5 eq 1 eq 36 2 111 mg 0.5 mmol Ni-cat2 — — Cs₂CO₃ 1 mmol 150 mg 5 mol % 1.5 eq 2 eq 1 eq 37 2 160 mg 0.5 mmol Ni-cat2 — — Cs₂CO₃ 1 mmol 150 mg 5 mol % 1.5 eq 2 eq 1 eq 38 2 0.5 mmol 5 bar Ni-cat2 — PhB-acid Cs₂CO₃ 40 mg 5 mol % 10 mol % 1.5 eq 1 eq 39 2 0.5 ml 0.2 mmol Ni-cat2 — — NaH 325 mg 130 mg 5 mol % 2 eq 4 eq 1 eq 40 2 0.5 ml 0.5 mmol Ni-cat2 — — NaOtBu 325 mg 175 mg 1 mol % 2 eq 4 eq 1 eq 41 2 0.5 ml 0.5 mmol Ni-cat2 — — NaOtBu 325 mg 275 mg 1 mol % 2 eq 4 eq 1 eq 42 2 0.5 ml 0.5 mmol Ni-cat2 — — NaOtBu 325 mg 180 mg 1 mol % 2 eq 4 eq 1 eq 43 2 0.5 ml 0.5 mmol Ni-cat2 — — NaOtBu 325 mg 150 mg 1 mol % 2 eq 4 eq 1 eq

TABLE 3 Ex Proc DRYAG Solvent T t Conv Sel Yield Remarks 1 1 4A-MS neat  50° C. 20 h 100%  65% 63% o-isomer: +21% 50 mg GCMS ¹⁹F-NMR 2 2 4A-MS neat  50° C. 20 h 97% 65% 63% o-isomer: +21% 50 mg GCMS ¹⁹F-NMR 3 1 4A-MS neat  50° C. 24 h 89% 60% 53% o-isomer: +21% 25 mg 5% PfP-H GCMS ¹⁹F-NMR 4 1 4A-MS neat  50° C. 24 h 65% 55% 36% o-isomer: +15% 25 mg 4% PfP-H GCMS ¹⁹F-NMR 5 1 4A-MS neat 100° C.  6 h 98% 73% 72% o-isomer: +17% 30mg 1% PfP-H GCMS ¹⁹F-NMR 6 1 4A-MS neat 100° C. 72 h 95% 81% 77% o-isomer: +8% 50 mg GCMS ¹⁹F-NMR 7 1 4A-MS neat 100° C. 16 h 84% 85% 71% o-isomer: +5% 25 mg 1% PfP-H GCMS ¹⁹F-NMR 8 1 4A-MS neat 100° C. 16 h 99% 68% 67% o-isomer: +20% 40 mg 1% PfP-H GCMS ¹⁹F-NMR 9 1 Na2SO4 neat  90° C. 24 h 98% 72% 71% o-isomer: +4% 25 mg 3% PfP-H GCMS ¹⁹F-NMR 10 2 — neat 100° C. 16 h 97% 77% 75% ¹⁹F-NMR 11 2 — neat 130° C. 16 h 91% 2-isomer: 35% 3-isomer: 15% 4-isomer: 40% ¹⁹F-NMR 12 2 — neat 120° C. 16 h 55% 2-isomer: 25% 3-isomer: 9% 4-isomer: 21% ¹⁹F-NMR 13 2 neat 100° C. 16 h 86% ¹⁹F-NMR 14 2 neat 100° C. 16 h 73% ¹⁹F-NMR 15 2 neat 100° C. 24 h 73% 2-isomer: 48% 4-isomer: 25% ¹⁹F-NMR 16 2 neat 130° C. 16 h 54% ¹⁹F-NMR 17 2 neat 130° C. 17 h 66% 3-isomer: 18% 4-isomer: 48% ¹⁹F-NMR 18 2 neat 120° C. 16 h 78% ¹⁹F-NMR 19 2 neat 100° C. 16 h 70% 2-isomer: 19% 4-isomer: 51% ¹⁹F-NMR 20 2 neat 100° C. 16 h 95% 3-isomer: 19% 6-isomer: 51% ¹⁹F-NMR 21 2 neat 100° C. 30 h 96% 3-isomer: 10% 4-isomer: 86% ¹⁹F-NMR 22 2 neat 120° C. 24 h 74% ¹⁹F-NMR 23 2 neat 130° C. 16 h 73% ¹⁹F-NMR 24 2 neat 130° C. 26 h 59% 2-isomer: 26% 3-isomer: 5% 4-isomer: 28% ¹⁹F-NMR 25 2 — neat 130° C. 16 h 96% ¹⁹F-NMR 26 2 — neat  80° C. 16 h 86% ¹⁹F-NMR 27 2 — neat 120° C. 16 h 55% ¹⁹F-NMR 28 2 — neat 130° C. 17 h 61% 2-isomer: 23% 4-isomer: 17% 5-isomer: 21% ¹⁹F-NMR 29 2 — neat 130° C. 26 h 51% 1-isomer: 40% 2-isomer: 11% ¹⁹F-NMR 30 2 — neat 120° C. 16 h 76% ¹⁹F-NMR 31 2 — neat 120° C. 22 h 50% ¹⁹F-NMR 32 22 — neat 100° C. 16 h 54% ¹⁹F-NMR 33 2 — C₆F₆ 100° C. 16 h 52% ¹⁹F-NMR 0.5 ml 34 2 — neat 100° C. 16 h 60% ¹⁹F-NMR 35 2 — neat 100° C. 16 h 80% 2-isomer: 41% 5-isomer: 39% ¹⁹F-NMR 36 2 — C₆F₆ 100° C. 16 h 80% ¹⁹F-NMR 0.5 ml 37 2 — C₆F₆ 100° C. 16 h 85% ¹⁹F-NMR 0.5 ml 38 2 — C₆F₆ 100° C. 16 h 72% ¹⁹F-NMR 1 ml 39 2 — neat  80° C. 16 h 100%  64% 64% ¹⁹F-NMR 40 2 — neat  50° C. 16 h 73% ¹⁹F-NMR 41 2 — neat  50° C. 16 h 89% ¹⁹F-NMR 42 2 — neat  50° C. 16 h 69% ¹⁹F-NMR 43 2 — neat  50° C. 16 h 61% ¹⁹F-NMR

Comparative Example

The entry 10 in Table 1 of Loy, R. N., et al., Organic Letters 2011, 13, 2548-2551, was repeated according to the detailed procedure given in the Supporting Information for said article, which is described under “Optimization procedure” on page S3 in connection with entry 9 in Table S4 on page S5.

The phosphine was BINAP.

[Pd] was Pd₂dba3.

The base was Cs₂CO₃.

The alkylhalogenid was perfluorohexyl bromide instead of perfluorohexyl iodide.

To a screw cap 1 dram vial was added base (0.4 mmol, 2 equiv), [Pd] (0.02 mmol, 10 mol %) and phosphine (0.04-0.08 mmol, 20-40 mol %). Benzene (1 mL) and perfluorohexyl bromide (43 microL, 0.2 mmol, 1 equiv) were added, and the resulting mixture was sealed with a Teflon-lined cap and heated in an aluminum reaction block with vigorous stirring for 15 h at 80° C. The reaction mixture was cooled to 23° C. and chlorobenzene (20 microL) was added as a GC internal standard. An aliquot (ca. 100 microL) was removed from the crude reaction mixture and passed through a plug of Celite, eluting with EtOAc (2 mL). This sample was then analyzed by GC, and the yield was determined by comparison to a calibration against the chlorobenzene internal standard.

Result:

A yield of less than 1% was measured. 

The invention claimed is:
 1. A method for preparation of a mono-fluoro alkylated compound FACOMPSUBST that is mono-fluoroalkylated at a sp2 carbon, by a reaction of a compound COMPSUBST with a fluoro alkyl halide FAHALIDE by homogeneous catalysis using a Ni catalyst NICAT in the presence of a base BAS; wherein NICAT is Ni-cat1 or Ni-cat2; Ni-cat1 is a combination of a nickel salt NISALT with a ligand LIG NISALT is NiCl₂ or Ni(NO₃)₂; LIG is selected from the group consisting of compound of formula (DPEPhos), compound of formula (dppb) and Ph₃P;

Ni-cat2 is compound of formula (Ni-cat2);

BAS is selected from the group consisting of Cs₂CO₃, CsHCO₃, K₃PO₄, NaH and NaOtBu; FAHALIDE is selected from the group consisting of perfluoro C₁₋₂₀ alkyl-X1, and Br—(CF₂)_(n3)—Br; wherein X1 is Br or I; with n3 being an integer of 2 to 10; COMPSUBST is selected from the group consisting of a compound COMPSUBST-I, ethene, and polystyrene; the ethene being substituted by 1 substituent selected from the group consisting of C₁₋₁₀ alkyl; COMPSUBST-I is a compound of formula (COMPSUBST-I); RINGA(COMPSUBST-I) RINGA is a 5 or 6 membered carbocyclic or heterocyclic ring, when RINGA is a heterocyclic ring, then RINGA has 1, 2 or 3 identical or different endocyclic heteroatoms independently from each other selected from the group consisting of N, O and S, when RINGA is a 5 membered ring, then RINGA is unsubstituted or substituted by 1, 2, 3 or 4 identical or different substituents, when RINGA is a 6 membered ring then RINGA is unsubstituted or substituted by 1, 2, 3, 4 or 5 identical or different substituents, any of the substituents of RINGA is independently from any other of the substituents of RINGA selected from the group consisting of C₁₋₁₀ alkyl, C₃₋₈ cycloalkyl, C₁₋₄ alkoxy, OH, N(R10)R11, CN, NH—OH, NO, NO₂, F, Cl, Br, I, CF₃, (CH₂)_(m)—C(O)Y1, S(O)₂R50, CH═C(H)R28, C

C—R24, benzyl, phenyl and naphthyl; RINGA can be condensed with a ring RINGB, RINGB is a 5 or 6 membered carbocyclic or heterocyclic ring, when RINGB is a heterocyclic ring, is contains 1, 2 or 3 identical or different endocyclic heteroatoms independently from each other selected from the group consisting of N, O and S; when RINGB is a 5 membered ring, then RINGB is unsubstituted or substituted by 1, 2 or 3 identical or different substituents, when RINGB is a 6 membered ring then RINGB is unsubstituted or substituted by 1, 2, 3 or 4 identical or different substituents, any of the substituents of RINGB is independently from any other of the substituents of RINGB selected from the group consisting of C₁₋₁₀ alkyl, C₃₋₈ cycloalkyl, C₁₋₄ alkoxy, OH, N(R17)R18, CN, NH—OH, NO, NO₂, F, Cl, Br, I, CF₃, (CH₂)_(n)—C(O)Y2, S(O)₂R51, CH═C(H)R38, C

C—R34, benzyl, phenyl and naphthyl; any of the C₁₋₁₀ alkyl substituent of RINGA or RINGB is unsubstituted or substituted with 1, 2, 3, 4 or 5 identical or different substituents selected from the group consisting of halogen, OH, O—C(O)—C₁₋₅ alkyl, O—C₁₋₁₀ alkyl, S—C₁₋₁₀ alkyl, S(O)—C₁₋₁₀ alkyl, S(O₂)—C₁₋₁₀ alkyl, O—C₁₋₆ alkylen-O—C₁₋₆ alkyl, C₃₋₈ cycloalkyl and 1,2,4-triazolyl; any of said benzyl, phenyl and naphthyl substituent of RINGA or RINGB is independently from each other unsubstituted or substituted with 1, 2, 3, 4 or 5 identical or different substituents selected from the group consisting of halogen, C₁₋₄ alkoxy, NO₂ and CN; m and n are identical or different and independently from each other 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; Y1 and Y2 are identical or different and independently from each other selected from the group consisting of H, OH, C(R14)(R15)R16, C₁₋₆ alkyl, O—C₁₋₆ alkyl, phenyl, benzyl, O-phenyl, O—C₁₋₆ alkylen-O—C₁₋₆ alkyl and N(R19)R20; R14, R15 and R16 are identical or different and independently from each other selected from the group consisting of H, F, Cl and Br; R10, R11, R17, R18, R19 and R20 are identical or different and are independently from each other H or C₁₋₆ alkyl, or R10 and R11, R17 and R18 or R19 and R20 represent together a tetramethylene or a pentamethylene chain; R50 and R51 are identical or different and independently from each other selected from the group consisting of OH, C₁₋₆ alkyl and C₁₋₆ alkoxy; R24, R34, R28 and R38 are identical or different and independently from each other selected from the group consisting of H, C₁₋₁₀ alkyl, C(R25)(R26)-O—R27; R25, R26 and R27 are identical or different and independently from each other selected from the group consisting of H and C₁₋₁₀ alkyl; and wherein if COMPSUBST is ethene as defined above, FACOMPSUBST is a 1,2-disubstituted ethene.
 2. The method according to claim 1, wherein LIG is compound of formula (DPEPhos) or Ph₃P.
 3. The method according to claim 1, wherein BAS is selected from the group consisting of Cs₂CO₃, K₃PO₄, NaH and NaOtBu.
 4. The method according to claim 1, wherein COMPSUBST is selected from the group consisting of compound COMPSUBST-I, ethene, and polystyrene; the ethene being substituted by 1 substituent selected from the group consisting of C₁₋₁₀ alkyl; with COMPSUBST-I being selected from the group consisting of

with COMPSUBST-I being unsubstituted or substituted by 1, 2, 3 or 4 in case of COMPSUBST-I being a monocyclic compound with 5 endocyclic atoms, by 1, 2, 3, 4 or 5 in case of COMPSUBST-I being a monocyclic compound with 6 endocyclic atoms, by 1, 2, 3, 4, 5 or 6 in case of COMPSUBST-I being a bicyclic compound wherein a 5-membered and a 6-membered ring are ortho-fused, by 1, 2, 3, 4, 5, 6 or 7 in case of COMPSUBST-I being a bicyclic compound wherein two 6-membered rings are ortho-fused, identical or different substituents independently from each other selected from the group consisting of C₁₋₁₀ alkyl, C₃₋₈ cycloalkyl, C₁₋₄ alkoxy, OH, C(H)═O, N(R10)R11, CN, NH—OH, NO, NO₂, F, Cl, Br, I, CF₃, (CH₂)_(m)—C(O)Y1, S(O)₂R50, CH═C(H)R28, C

C—R24, benzyl, phenyl and naphthyl; said C₁₋₁₀ alkyl substituent of COMPSUBST-I is unsubstituted or substituted with 1, 2, 3, 4 or 5 identical or different substituents selected from the group consisting of halogen, OH, O—C(O)—C₁₋₅ alkyl, O—C₁₋₁₀ alkyl, S—C₁₋₁₀ alkyl, S(O)—C₁₋₁₀ alkyl, S(O₂)—C₁₋₁₀ alkyl, O—C₁₋₆ alkylen-O—C₁₋₆ alkyl, C₃₋₈ cycloalkyl and 1,2,4-triazolyl; said benzyl, phenyl and naphthyl substituents of COMPSUBST-I are independently from each other unsubstituted or substituted with 1, 2, 3, 4 or 5 identical or different substituents selected from the group consisting of halogen, C₁₋₄ alkoxy, NO₂ and CN.
 5. The method according to claim 1, wherein COMPSUBST-I is unsubstituted or substituted by 1, 2 or 3 in case of COMPSUBST-I being a monocyclic compound with 5 endocyclic atoms, by 1, 2, 3, 4 or 5 in case of COMPSUBST-I being a monocyclic compound with 6 endocyclic atoms, by 1, 2, 3 or 4 in case of COMPSUBST-I being a bicyclic compound wherein a 5-membered and a 6-membered ring are ortho-fused, by 1, 2, 3, 4 or 5 in case of COMPSUBST-I being a bicyclic compound wherein two 6-membered rings are ortho-fused, identical or different substituents independently from each other selected from the group consisting of C₁₋₄ alkyl, C₁₋₄ alkoxy, OH, C(H)═O, N(R10)R11, CN, F, Cl, Br, CF₃, (CH₂)_(m)—C(O)Y1, and S(O)₂R50; said C₁₋₄ alkyl substituent of COMPSUBST-I is unsubstituted or substituted with 1, 2 or 3 identical or different substituents selected from the group consisting of halogen.
 6. The method according to claim 1, wherein COMPSUBST is selected from the group consisting of

 ethene, and polystyrene; Y is C₁₋₆ alkyl; the ethene being substituted by 1 substituent selected from the group consisting of C₁₋₁₀ alkyl.
 7. The method according to claim 1, wherein n3 is 2, 3, 4, 5,
 6. 8. The method according to claim 1, wherein FAHALIDE is selected from the group consisting of F₂₁C₁₀—I, F₂₁C₁₀—Br, F₁₇C₈—Br, F₁₃C₆—Br, F₉C₄—Br, F₇C₃—Br, F₃C—Br, Br—(CF₂)₄—Br, F₂HC—I, and F₂HC—Br.
 9. The method according to claim 1, wherein the reaction is done in the presence of a drying agent DRYAG; wherein DRYAG is selected from the group consisting of molecular sieve and Na₂SO₄.
 10. The method according to claim 1, wherein the reaction is done neat or in a solvent SOL.
 11. The method according to claim 10, wherein SOL is selected from the group consisting of alkanes, chlorinated alkanes, ketones, ethers, esters, aliphatic nitrils, aliphatic amides, sulfoxides, C₆F₆, and mixtures thereof. 